Two elderly patients with a history of either cerebral vascular accident (CVA) or head trauma and no evidence of renal disease developed seizures while. exantema y prurito. La toxicidad neurológica, aunque rara, es más frecuente tras la administración de Imipenem/Cilastatina. La aparición de convulsiones con. Incidence Most antibiotics are CNS-safe, and neurotoxicity associated with their administration is infrequent There have been anecdotal.

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A convulsions seizure occurred in 4 patients Hypomagnesemia can induce epileptic seizures, 2728 and Van Paesschen et al 8 emphasize metabolic causes as important in HIV-infected patients. Metabolic derangements hypoglycemia and hypomagnesemia were observed in 2 iipenem First seizure in adults: A randomized, controlled trial of foscarnet in the treatment of cytomegalovirus retinitis in patients with AIDS.

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Purchase access Subscribe now. Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more. Prior to their first seizure, 14 patients Etiologic and Clinical Aspects. Enferm Infecc Microbiol Clin. Create a free personal account to access your subscriptions, sign up for alerts, and more. In other reports, sexual transmission was the convulsioes common risk factor.


The risk of seizures among the carbapenems: a meta-analysis.

Purchase access Subscribe to JN Learning for one year. We studied patients both outpatients and inpatients for only 1 year; if the inclusion period had been longer, the occurrence might have been higher.

Any patient imipenm a first seizure during this 1-year period was examined by physicians from the Department of Neurology and followed up quarterly until death or study end. All 17 patients had a generalized seizure at some time.

The risk of seizures among the carbapenems: a meta-analysis.

AIDS-associated progressive multifocal leukoencephalopathy revealed by new-onset seizures. Generalized tonic-clonic seizures were the most common, and a focal seizure suggested a structural cerebral lesion. Clinical data recorded for each patient were age, sex, HIV risk factors, first seizure date, toxic drug use, latency between diagnosis of HIV infection and first seizure, stage of disease, prior anti-HIV treatments, neurologic complications related to HIV, nonneurologic complications, and seizure characteristics duration, interval between seizures, precipitating drugs, frequency, and clinical seizure type based on the International Classification of Epileptic Seizures of 7.

Human immunodeficiency virus risk factors were intravenous drug use IVDU in 10 patients 5 menhomosexual activity in 4 all menand heterosexual transmission in 3 1 woman. We were able to identify the cause of seizure in Drug toxicity was considered a definite or probable cause when the time was close between use of the drug and the seizure.

We found partial seizures in No complex partial seizures were observed. None of the patients with status epilepticus had these disorders. J Neurol Neurosurg Psychiatry.

Seizures were refractory to therapy in 3 patients Seizures directly related to substance use, abuse, and withdrawal are increasingly common. Any patient with prior seizures with or without relation to HIV was excluded from the study. Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more.


Van Paesschen et al 8 report a higher occurrence of status epilepticus in patients with IVDU than in other risk factor groups.

Since the number of HIV-infected patients with first seizure in our study is relatively low, seizure characterization is limited. Calcium and magnesium levels in 1 patient were normal.

Two patients imippenem seizures related to metabolic derangements. Mean follow-up was 5. Privacy Policy Terms of Use. Convulsiones inducidas por imipenem en una paciente HIV-positiva [letter].

Sign in to make a comment Sign in to your personal account. While seizures tended to be well controlled with the use of phenytoin, the duration of follow-up is insufficient to estimate effectiveness.

Progressive multifocal leukoencephalopathy in AIDS: Neurotoxicity due to use of zidovudine has been long recognized as a cause of epileptic seizures. Toxic-metabolic factors were imipenfm the cause of the seizure in 10 patients In 1 patient, imipenem produced a GTC seizure, a well-known adverse effect.

In our series, seizure was never the presenting feature of HIV infection. All generalized seizures were tonic-clonic, except for 1 patient who had myoclonic seizures.